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Data Availability: All relevant data are within the paper and its Supporting Information files.

Funding: This work was supported in part by the National Institutes of Health, National Institute of Allergy and Infectious Diseases grants (R01AI054578; R01AI136031) to NJG and National Institute of General Medical Sciences grant (R01GM11059) to YWY. A mini-center pilot grant (to NJG) and data acquisition award (to JJW) from the Institute for Human Infections and Immunity, UTMB, Galveston also supported part of the presented studies. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing interests: The authors have declared that no competing interests exist.