Their findings debunked the claims of Canola oil marketers, demonstrating negative impacts to bodies and brains.
Mice who were chronically exposed to canola oil experienced a significant increase in body weight; a gain of nearly one-fifth of total weight recorded just six months earlier. Effects on the brain were equally undesirable. Mice showed impairments in their working memory, demonstrated by decreased problem-solving abilities. Together with reduced levels of beneficial brain proteins that mark synaptic integrity, or how well neurons are firing, the mice performed significantly worse on all tests as compared to control mice. Synaptic integrity can affect whether or not critical connections are made in the brain, something that is vital to a functional memory and enjoying a high quality of life. Canola oil impairs synaptic integrity, which greatly exacerbates the debilitating symptoms of Alzheimer’s disease.
Researchers concluded that their findings do not support the beneficial effect of regular canola oil consumption, nor does their data justify the current trend aimed at replacing olive oil with canola oil in your diet. Not when research has consistently shown that olive oil reduces the same brain plaques and unhealthy proteins that canola oil increases. The same way that Big Pharma selectively publishes only favorable scientific research on drugs, canola oil producers have cherry-picked data that is both contradictory and inconclusive when viewed in its entirety. Meanwhile, consumption of extra virgin olive oil continues to deliver on its promise of being a true superfood.
A similar study was conducted by the same Temple University research group in June 2017, but this time the focus was on olive oil and its effects on Alzheimer’s brain plaques and tangles. Mice were fed a diet of normal food, or food supplemented with extra virgin olive oil for six months. Compared with controls, the group fed olive oil demonstrated improvements in their prior behavioral deficits. Synaptic integrity also improved, thanks to a significant increase in steady-state levels of synaptophysin, a protein marker of synaptic integrity. In addition, brain plaque deposition decreased, thanks to reductions in insoluble peptides and specific proteins associated with the disease. Overall, their findings supported the beneficial effect of olive oil consumption on all major features of Alzheimer’s disease.
 auretti E, Pratico D. Effect of canola oil consumption on memory, synapse and neuropathology in the triple transgenic mouse model of Alzheimer’s disease.Sci Rep. 2017 Dec 7;7(1):17134. doi: 10.1038/s41598-017-17373-3.
 Extra-virgin olive oil attenuates amyloid-? and tau pathologies in the brains of mice. Qosa H, Mohamed LA, Batarseh YS, Alqahtani S, Ibrahim B, LeVine H 3rd, Keller JN, Kaddoumi A. J Nutr Biochem. 2015 Dec; 26(12):1479-90.
 Effects of diets containing olive oil, sunflower oil, or rapeseed oil on the hemostatic system. Junker R, Kratz M, Neufeld M, Erren M, Nofer JR, Schulte H, Nowak-Gottl U, Assmann G, Wahrburg U. Thromb Haemost. 2001 Feb; 85(2):280-6.
 Lauretti E, Iuliano L, Pratico D. Extra-virgin olive oil ameliorates cognition and neuropathology of the 3xTg mice: role of autophagy. Ann Clin Transl Neurol. 2017 Jun 21;4(8):564-574. doi: 10.1002/acn3.431. eCollection 2017 Aug.
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