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    The number of remote jobs has risen 115% since 2005, according to FlexJobs, a job-search site for remote work, and the number of people quitting their jobs for flexible work has doubled from 2014 to 2017.

    There is evidence that telecommuters are more productive, according to a 2017 study of 24,000 workers from the video and voice collaboration technology company Polycom Inc. and the human-resources executive network and research firm Future Workplace. Some 98% of people said the ability to work anywhere has a positive impact on productivity, and 62% said they are already taking advantage of flexible set-ups for work.

    But working from home in a different state from your company’s home office isn’t for everyone: It can impede an employee’s ability to advance in the company, Bakr said. “You can’t manage as easily remotely,” he said. “You don’t have the day-to-day exposure to leadership.”

    Vermont was No. 9 in a recent U.S. & World Report ranking of the best states in which to live, based on 77 different metrics, including public health, employment, affordability, environment, broadband access, growth and quality of life.

    Read next: California’s emigrants aren’t all moving to cheaper housing markets

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    PARP1/PAR effects on mitochondrial function and antioxidant/oxidant balance

    The mtDNA encodes for essential components of respiratory complexes and its deficiency can directly disturb the mitochondrial function. We, therefore, monitored if PARP1/PAR affect the OXPHOS capacity in chagasic myocardium. No significant differences in the basal level of mitochondrial respiration and state 4 respiration driven by CI or CII substrates were observed in the myocardial fibers of WT and PARP1-/- mice in presence or absence of chronic Tc infection. The CI and CII substrates driven ADP-coupled state 3 respiration (indicates proton gradient for ATP synthesis) as well as respiratory control ratio (RCR, state 3 / state 4) were maintained to normal levels in chronically infected PARP1-/- mice (Fig 4A, 4B and 4D). In comparison, we noted a 29% and 61% decline in CI- and CII-energized state 3 respiration, respectively (Fig 4A & 4B), and a 48% decline in CII-supported RCR (Fig 4D, all, p<0.05) in the myocardial fibers of WT.Tc (vs. WT) mice. Addition of cytochrome c did not improve the CII driven state 3 respiration in myocardial fibers of WT.Tc mice, thus, confirming that mitochondrial membranes were not damaged during experimental procedure (Fig 4C).

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