5 Star
.
.

AveXis’s gene therapy is meant to be a one-time treatment, infused into a vein during a 60-minute procedure. It uses an engineered virus to deliver healthy copies of the SMN1 gene to cells throughout the body. Once there, the new gene starts making a protein that’s essential for the survival of motor neurons.

If you wait, however, “the children have limited motor neurons for the gene therapy to get into and work effectively,” says Sukumar Nagendran, AveXis’s chief medical officer.

On average, the 15 children in the AveXis trial received the gene therapy four months after birth. They all responded, but Nagendran says two children who got it within the first two months of life had the most dramatic improvement; they’re now able to walk independently.

In April, AveXis began a new study, this time treating babies immediately after birth. The results will be able to tell researchers just how much better patients fare when they get the drug as newborns.

Other gene therapies may also work better in children before a genetic defect has time to irreparably damage the body. For example, Bluebird Bio is developing one that halted a deadly brain disorder called cerebral adrenoleukodystrophy (ALD), also known as Lorenzo’s Oil disease, in 15 out of 17 children. In a statement provided to MIT Technology Review, the company said outcomes are better when patients are treated before symptoms appear.

State by state

On February 8, a national committee that oversees newborn testing voted to recommend that SMA be added to the recommended universal screening panel. The next step is for the secretary of the US Department of Health and Human Services, Alex Azar, to sign off.

Even then, rolling out SMA screening for every newborn isn’t a done deal. A recommendation put forth by the committee is just that—a recommendation. It’s only binding in two states, California and Florida. Other states may choose to adopt the proposal or not.

.
.
.
.
.

 

http://game-rapidshare.com/Pompi-daughter-of-Guitierez-from-Verpillières-sur-ource?Magrannne=114
.
.

In West Bengal, one more patient with mysterious fever, suspected to be infected by Nipah virus, was on Tuesday ( May 29) admitted to ID Hospital in Beliaghata here. Further, samples sent from cattle and pigs in the vicinity that were also sent tested negative for Nipah virus. This was the first NiV outbreak in South India. Doctors suspect the virus had spread from a 26-year-old, triggering an outbreak in Kozhikode.

According to the WHO report, 600 Nipah cases were reported in the world from 1998 to 2015.

"We had taken him to Domkol hospital, then to Baharampur and finally here after consultation with the medics there", they said. A multi-disciplinary team led by the Indian Government's National Centre for Disease Control (NCDC) is in Kerala in response to the outbreak.

Wall Street falls on Italy political crisis
The yield on the 10-year Treasury fell to 2.78 percent, its lowest since early April, from 2.93 percent. Trader Peter Tuchman works on the floor of the New York Stock Exchange, Tuesday, May 29, 2018.

Dr M says MH370 search may resume if new evidence found
Ocean Infinity took over on a no-find, no fee-basis after a search by Malaysia, Australia and China failed to find the plane. The previous 2.5-year search, coordinated by the governments of Australia, Malaysia and China, cost 0 million.

West Indies win big against Tamim’s World XI
While some reports are saying the match will be telecast on Sony SIX and Sony SIX HD, there is no official confirmation. Shahid Afridi receives Guard of honour during exhibition match between World XI and West Indies .

Symptoms of the infection include fever, headache, drowsiness, respiratory illness, disorientation and mental confusion, and patients progress into a coma within 24-48 hours.

The good thing is the government of India has capacity to deal with Nipah.

However, the disease itself was contained quickly before it could become an outbreak.

"Most of the devastating infectious diseases in human history began as infections that spilled over from animals and people and then acquired the capacity for efficient person-to-person transmission", he explained. And despite there being an abundance of the type of bat that carries Nipah, the body of evidence suggests that the virus is rarely found even in these bats.

.
.
.

Walking with the Wounded’s Walk of America, a 12-week expedition from Los Angeles to New York City, is intended to raise awareness of mental health among veterans and to raise funds to support wounded British and American veterans.

.

9 in Times Higher Education World Reputation Rankings

.
.