The indices of LV systolic function, i.e., stroke volume (SV), cardiac output (CO), and ejection fraction (EF), were decreased by 66%, 51% and 46% respectively, in WT.Tc (vs. WT) mice (Fig 7A–7C, all, p<0.01). The systolic dysfunction prolonged the pre-ejection isovolumic contraction time (IVCT, 74% increase, Fig 7D, p<0.05) and shortened the LV ejection time (LVET, Fig 7E, p<0.05) in chagasic mice. Further, 40–67% changes in the early (E) and late (A) diastolic filling velocities indicated diastolic dysfunction in chagasic WT mice (Fig 7F & 7G, all, p<0.05). Both systolic and diastolic dysfunction contribute to abnormality in myocardial relaxation that was presented by 50% increase in isovolumic relaxation time (IVRT, Fig 7H, p<0.05) in WT.Tc mice. In comparison to WT.Tc mice, PARP1+/-.Tc and PARP1-/-.Tc mice exhibited a partial-to-full control of systolic and diastolic dysfunction, and myocardial contraction and relaxation indices, the maximal benefits of PARP1 deletion being observed in PARP1-/- mice (Fig 7A–7H)..
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The report comes the day after research was released showing around half of television food and drink adverts seen by children are for HFSS products or for fast food restaurants.
The advertising of junk food products has been banned during children’s programmes since 2007 but the Institute for Fiscal Studies (IFS) on Thursday found that 70% of TV campaigns for HFSS products or restaurants and bars are screened prior to the 9pm watershed.
Evidence from Ofcom suggests that in 2016 children spent 64% of their viewing time watching television outside children’s programming.
On Wednesday, the Health and Social Care Select Committee said cartoon characters should be banned from promoting junk food to improve childhood obesity rates.
Such a ban would mean that characters such as Tony the Tiger and the Milky Bar Kid would have to be dropped or used to promote healthier products. And cartoon characters from the latest summer blockbuster would no longer appear on the packaging or adverts for fast food.
A Department of Health and Social Care spokeswoman said: “We’ve always said that our 2016 plan was the start of the conversation, not the final word on obesity.
“We are in the process of working up an updated plan, and will be in a position to say more shortly.”