Citation: Wen JJ, Yin YW, Garg NJ (2018) PARP1 depletion improves mitochondrial and heart function in Chagas disease: Effects on POLG dependent mtDNA maintenance. PLoS Pathog 14(5): e1007065. https://doi.org/10.1371/journal.ppat.1007065
Editor: Margaret A. Phillips, U Tex SouthWestern, UNITED STATES
Received: November 6, 2017; Accepted: April 30, 2018; Published: May 31, 2018
Copyright: © 2018 Wen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: All relevant data are within the paper and its Supporting Information files.
Funding: This work was supported in part by the National Institutes of Health, National Institute of Allergy and Infectious Diseases grants (R01AI054578; R01AI136031) to NJG and National Institute of General Medical Sciences grant (R01GM11059) to YWY. A mini-center pilot grant (to NJG) and data acquisition award (to JJW) from the Institute for Human Infections and Immunity, UTMB, Galveston also supported part of the presented studies. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.