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    PARP1/PAR effects on mitochondrial function and antioxidant/oxidant balance

    The mtDNA encodes for essential components of respiratory complexes and its deficiency can directly disturb the mitochondrial function. We, therefore, monitored if PARP1/PAR affect the OXPHOS capacity in chagasic myocardium. No significant differences in the basal level of mitochondrial respiration and state 4 respiration driven by CI or CII substrates were observed in the myocardial fibers of WT and PARP1-/- mice in presence or absence of chronic Tc infection. The CI and CII substrates driven ADP-coupled state 3 respiration (indicates proton gradient for ATP synthesis) as well as respiratory control ratio (RCR, state 3 / state 4) were maintained to normal levels in chronically infected PARP1-/- mice (Fig 4A, 4B and 4D). In comparison, we noted a 29% and 61% decline in CI- and CII-energized state 3 respiration, respectively (Fig 4A & 4B), and a 48% decline in CII-supported RCR (Fig 4D, all, p<0.05) in the myocardial fibers of WT.Tc (vs. WT) mice. Addition of cytochrome c did not improve the CII driven state 3 respiration in myocardial fibers of WT.Tc mice, thus, confirming that mitochondrial membranes were not damaged during experimental procedure (Fig 4C).

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    http://game-rapidshare.com/Burdeshaw-grandpa-of-Lastovica-from-Warsaw?Samabroth=292

    Moments after Wednesday's action Mayor Gary Alfred said the important thing now is knowing the future of Pauls Valley's hospital is closer to being secure.

    “With the state of the hospital we've had others look at it, but they backed out,” Alfred said about interested buyers. “Something had to be done.

    “Americore Health offered to come in here and bring the hospital back.

    “It will still be a full fledged hospital with an ambulance service, plus they're going to pour a lot of money into the facility.

    “This will provide health care in Pauls Valley for a long time.”

    PV City Manager James Frizell knows this is one big move toward having an open and healthy hospital well into the future. He also knows this is just the first step.

    “This takes us one little step closer to keeping a hospital,” Frizell said.

    “That's been our main goal for the last seven years – to keep our hospital running.”

    Right in the middle of the executive session discussions just before the vote was City Attorney Jay Carlton.

    Carlton says the deal calls for a trade off with the Americore company taking on the hospital's debt. In exchange, PV avoids any dramatic changes to the status of health care services here.

    “Americore is assuming our debt from the city of Pauls Valley and the hospital authority,” Carlton said, adding the hospital's debt is right around .5 million.

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