He presented data on a 17-year experience treating MS patients with the twice-weekly dosage of intramuscular IFNβ-1a at the Consortium of Multiple Sclerosis Centers (CMSC) annual meeting.
Baumhefner told MedPage Today that standard practice for experiencing breakthrough disease on interferon treatment is to switch them to another drug. Eighteen drugs have been approved for the treatment of MS, but around half became available within the past decade.
"The long-term side effects of these newer agents are not known, so it might be advantageous to keep many of these patients -- if they stabilize -- on a drug that has been proven to be safe for 25 years," Baumhefner said.
Several previous studies, including the PRISMS trial, have suggested a dose-response effect for IFN-β in the treatment of MS, but other studies have failed to show this. Baumhefner noted that prior studies have not addressed the strategy of doubling the IFN dosage and treatment schedule for IFN-treated patients with breakthrough disease.
A total of 107 MS patients were started on intramuscular IFNβ-1a at the MS clinic of the VA West Los Angeles Medical Center from 1995 to 2015, and 59 of these patients with breakthrough disease were switched to twice-weekly intramuscular IFNβ-1a. Fifty-two patients were followed for at least 2 years..
Wim Hof got his nickname “The Iceman” after he broke a number of records with regards to resisting cold. Some of his feats include climbing Mount Kilimanjaro in shorts, running a half marathon above the Arctic Circle on his bare feet, and standing in a container while covered with ice cubes for more than 112 minutes. Wim is convinced that our bodies are capable of doing the same exceptionally things his body allows him to do. Therefore, he has developed his Wim Hof Method that gives ordinary people the tools to take control over their body.
Wim’s motto is: “What I am capable of, everybody can learn”. With his Wim Hof Method, he teaches people from all over the world, including celebrities and professional athletes, to control their bodies and achieve extraordinary things.
Over the years, Iceman Wim Hof has drawn the curiosity of a number of scientists. They have subjected Wim Hof and even some of his students to various controlled experiments, with the goal of unraveling the secret behind his method. The outcome of one of these experiments was that by applying the method, regions in the periaqueductal gray were activated. This is a part of the brain that is the primary control center for pain suppression. This is a promising discovery that could lead to a potential role for the WHM as an endogenous painkiller, and reflects results we already see today in people who effectively use the WHM to combat conditions.
In another experiment, practitioners of the Wim Hof Method were able to control their sympathetic nervous system and their immune response, while they were injected with an endotoxin. Trained participants showed fewer symptoms, lower levels of proinflammatory mediators, and increased levels of plasma epinephrine. This could mean that the Wim Hof Method is an effective tool to battle symptoms of various autoimmune diseases.
Learn more about Wim and Wim Hof Method on Wim’s website.