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FILE - In this Thursday, Aug. 18, 2016 file photo soft drinks are on display at a supermarket in London. An independent World Health Organization panel is backing away from the U.N. health agencys own call two years ago for taxing sugary drinks, in The Associated Press
FILE - In this Thursday, Aug. 18, 2016 file photo soft drinks are on display at a supermarket in London. An independent World Health Organization panel is backing away from the U.N. health agency's own call two years ago for taxing sugary drinks, in a new report on diseases like cancer, obesity and diabetes that some experts slammed as being "conspicuously limp." (AP Photo/Frank Augstein, File)
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http://game-rapidshare.com/Loredo-grandpa-of-Rieffenberger-from-Houtain-le-val?Trizarryb=231
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PARP1/PAR effects on mitochondrial function and antioxidant/oxidant balance

The mtDNA encodes for essential components of respiratory complexes and its deficiency can directly disturb the mitochondrial function. We, therefore, monitored if PARP1/PAR affect the OXPHOS capacity in chagasic myocardium. No significant differences in the basal level of mitochondrial respiration and state 4 respiration driven by CI or CII substrates were observed in the myocardial fibers of WT and PARP1-/- mice in presence or absence of chronic Tc infection. The CI and CII substrates driven ADP-coupled state 3 respiration (indicates proton gradient for ATP synthesis) as well as respiratory control ratio (RCR, state 3 / state 4) were maintained to normal levels in chronically infected PARP1-/- mice (Fig 4A, 4B and 4D). In comparison, we noted a 29% and 61% decline in CI- and CII-energized state 3 respiration, respectively (Fig 4A & 4B), and a 48% decline in CII-supported RCR (Fig 4D, all, p<0.05) in the myocardial fibers of WT.Tc (vs. WT) mice. Addition of cytochrome c did not improve the CII driven state 3 respiration in myocardial fibers of WT.Tc mice, thus, confirming that mitochondrial membranes were not damaged during experimental procedure (Fig 4C).

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