As part of Burn Pits 360, Diane advocates on behalf of soldiers, veterans and their families to get them the specialized care needed to care for some of the serious diseases caused by exposure to toxins from burn pits and other airborne hazards.
Chagasic cardiomyopathy is caused by Trypanosoma cruzi infection. Poly(ADP-ribose) polymerase 1 (PARP1) is known for its function in nuclear DNA repair. In this study, we have employed genetic deletion and chemical inhibition approaches to determine the role of PARP1 in maintaining mtDNA dependent mitochondrial function in Chagas disease. Our data show that expression of PARP1 and protein PARylation were increased by >2-fold and >16-fold, respectively, in the cytosolic, nuclear, and mitochondrial fractions of the human cardiac myocytes and the myocardium of wildtype (WT) mice chronically infected with T. cruzi. The nuclear and cytosolic PARP1/PAR did not interfere with the transcription and translation of the components of the mtDNA replisome machinery in infected cardiomyocytes and chagasic murine myocardium. However, PARP1 binding to Polymerase ? and mtDNA in mitochondria were increased, and associated with a loss in mtDNA content, mtDNA-encoded gene expression, and oxidative phosphorylation (OXPHOS) capacity, and an increase in mitochondrial ROS production in cells and heart of WT mice infected with T. cruzi. Subsequently, an increase in oxidative stress, and cardiac collagen deposition, and a decline in LV function was noted in chagasic mice. Genetic deletion of PARP1 or treatment with selective inhibitor of PARP1 (PJ34) improved the mtDNA content, mitochondrial function, and oxidant/antioxidant balance in human cardiomyocytes and chronically infected mice. Further, PARP1 inhibition was beneficial in preserving the cardiac structure and left ventricular function in chagasic mice. We conclude that PARP1 overexpression is associated with a decline in Pol ?-dependent maintenance of mtDNA content, mtDNA-encoded gene expression, and mitochondrial respiratory function, and subsequently contributes to an increase in mtROS and oxidative stress in chagasic myocardium. Inhibition of mitochondrial PARP1/PAR offers a novel therapy in preserving the mitochondrial and LV function in chronic Chagas disease.
As the country joined the worldwide community to mark the 2018 world no tobacco day, we focus on enforcement of the National tobacco control act 2015. Whilst there are many methods to help people quit smoking, many studies have shown that carbon monoxide (CO) monitoring has proven to be very effective in monitoring and encouraging a person's quit attempt and this World Tobacco Day you have the chance to win a personal CO monitor.
"Due to the presence of nicotine and other chemicals, prolonged use of SLT causes serious health issues such as cancer and heart disease".
"Smoking harms almost every organ in the body, and more than 16 million Americans are living with a disease caused by smoking", said Albert Rizzo, M.D., senior medical advisor to the American Lung Association.
These include making indoor public and workplaces smoke-free and insisting that tobacco packaging carries warnings that demonstrate the health risks for users.
"Most people know that using tobacco causes cancer and lung disease, but many aren't aware that tobacco also causes heart disease and stroke - the world's leading killers", said Dr Tedros Adhanom Ghebreyesus, WHO Director-General.
Over the years, WHO and multilateral health agencies have encouraged global tobacco regulations and advocacy on the potential health risks of tobacco consumption.
Not enough progressWHO and its member states established "World No Tobacco Day" in 1987 to draw attention to the widespread prevalence of tobacco use and to its negative effects on health.More news: The US President: ‘Great meeting with @KimKardashian, talked prison reform’
"Tobacco breaks hearts. Tobacco use and exposure to second-hand smoke contribute to about 12% of all heart disease deaths".
"In the two years since the Royal College of Physicians found that "harm reduction has huge potential to prevent death and disability from tobacco use", we continue to largely ignore the fact that many smokers do not want to quit, but obtain pleasure from smoking". Research suggests that people who manage to go 28 days without smoking during Stoptober are five times more likely to be successful long term.
After 10 years of quitting smoking, your risk of lung cancer falls to about half that of a smoker and your risk of cancer of the mouth, throat, esophagus, bladder, cervix, and pancreas decreases.
He further said that the government also compromised on tobacco tax this year as well by accommodating the tobacco industry by continuation of the third tier which allows most selling brands with least tax.
However, the United States is now not on track, bogged down by litigation over warnings on cigarette packaging and lags in taxation, said Vinayak Prasad of the WHO's tobacco control unit. Not smoking tobacco is one of the few key habits individuals can cultivate for their health and the health of their families.
She also said that raising the price of cigarettes will improve the health of everyone. The report shows that worldwide, 27% smoked tobacco in 2000, compared to 20% in 2016.
In the world of 1.1 billion smokers, more than 60% of them belong to Asian countries..