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FilmsHeartbreaking true story behind Adrift the movie - the real-life tale is far more harrowing than the filmShailene Woodley and Sam Claflin star in Adrift, the harrowing and heartbreaking real story based on Tami Oldham Ashcraft's book
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PARP1/PAR effects on mitochondrial function and antioxidant/oxidant balance

The mtDNA encodes for essential components of respiratory complexes and its deficiency can directly disturb the mitochondrial function. We, therefore, monitored if PARP1/PAR affect the OXPHOS capacity in chagasic myocardium. No significant differences in the basal level of mitochondrial respiration and state 4 respiration driven by CI or CII substrates were observed in the myocardial fibers of WT and PARP1-/- mice in presence or absence of chronic Tc infection. The CI and CII substrates driven ADP-coupled state 3 respiration (indicates proton gradient for ATP synthesis) as well as respiratory control ratio (RCR, state 3 / state 4) were maintained to normal levels in chronically infected PARP1-/- mice (Fig 4A, 4B and 4D). In comparison, we noted a 29% and 61% decline in CI- and CII-energized state 3 respiration, respectively (Fig 4A & 4B), and a 48% decline in CII-supported RCR (Fig 4D, all, p<0.05) in the myocardial fibers of WT.Tc (vs. WT) mice. Addition of cytochrome c did not improve the CII driven state 3 respiration in myocardial fibers of WT.Tc mice, thus, confirming that mitochondrial membranes were not damaged during experimental procedure (Fig 4C).

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You're all going to die' - Parkland shooter's phone videos released

Nikolas Cruz recorded several videos announcing his plans to kill up to 20 people at his high school in Parkland, FL. He doesn't want the shooter to get more publicity, but he believes the recordings are very important evidence.
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